Long-chain fatty acids have tails of 13 to 21 carbons. The team studied how two ELOVL4 mutants, one associated with brain disorders and the other with skin disease in humans, elongate a precursor fatty acid. They found that both these mutations had some limited capacity to elongate PUFA precursors to VLC-PUFA but blunted the enzyme’s capability to biosynthesize VLC-SFAs. “Because we know which VLCFAs go down with the different ELOVL mutations, we could recommend personalized dietary supplementations as part of the treatment.”

Improving the decision to switch from first- to second-line therapy in multiple sclerosis: A dynamic scoring system Mult Scler. Dayan CM, Lecumberri B, Muller I, Ganesananthan S, Hunter SF, Selmaj KW, Hartung HP, Havrdova EK, LaGanke CC, Ziemssen T, Van Wijmeersch B, Meuth SG, Margolin DH, Poole EM, Baker DP, Senior PA. Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies Mult Scler J Exp Transl Clin. - A swiss single center cross-sectional study Mult Scler Relat Disord.

In terms of measuring telomere length at individual chromosomal ends or to characterize the length distribution of individual telomeres, the new telomere length measurement technique has the added advantage of being easy to use and producing high throughput estimates—up to 72 patient samples in a single run so far. Steps are then taken to enrich the telomere repeat-containing genomic DNA fragments using these telobaits in PacBio high fidelity sequencing.

In terms of measuring telomere length at individual chromosomal ends or to characterize the length distribution of individual telomeres, the new telomere length measurement technique has the added advantage of being easy to use and producing high throughput estimates—up to 72 patient samples in a single run so far. Steps are then taken to enrich the telomere repeat-containing genomic DNA fragments using these telobaits in PacBio high fidelity sequencing.

Fifty years after the term brain–computer interface was coined, the neurotechnology is being pursued by an array of start-up companies using a variety of different technologies. All prices are NET prices. VAT will be added later in the checkout. Tax calculation will be finalised during checkout.

Researchers at Oxford Population Health and King’s College London have found that people with high levels of some triglyceride-carrying apolipoproteins may still be two to three times more likely to develop coronary heart disease even if their LDL-cholesterol levels are under control. Despite having optimal levels of LDL-cholesterol as a result of taking statins, some people may still have a ‘residual’ risk of developing cardiovascular disease.

“Our lab experiments showed that the young and old proteins can bind to each other – and in doing so possibly influence each other,” says lead author Dr. Jana Schulz, a researcher in Hübner’s team and at the DZHK. “If a microprotein binds to another protein, it doesn’t necessarily mean that it will influence the workings of the other protein or the processes that the protein is involved in,” says Schulz.

Serology based on antibody detection or quantification is a key research tool in the analysis of human infectious diseases. With a similar purpose of these benchmark studies, Girl et al. evaluated the performance of 2 lateral flow assays and 2 surrogate ELISA tests to detect SARS-CoV-2-neutralizing antibodies using data from more than 300 German individuals.

To date, approaches for measuring biological aging based on telomere length have been limited as they can only ascertain average telomere lengths within a pool of DNA fragments, or they are time-consuming and require highly-skilled specialists. Being able to accurately and efficiently measure the length of an individual's telomeres could open the doors to developing lifestyle interventions that slow aging and prevent disease.

Want to listen to this article for FREE? To date, approaches for measuring biological ageing based on telomere length have been limited as they can only ascertain average telomere lengths within a pool of DNA fragments, or are time-consuming and require highly-skilled specialists. Being able to accurately and efficiently measure the length of an individual’s telomeres could open the doors to developing lifestyle interventions that slow ageing and prevent disease.