Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia. Clonal hematopoiesis and risk of chronic liver disease. Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level.

"It is of great clinical significance to develop a new noninvasive, accurate radiomics method to evaluate PD-L1 expression levels and predict and filter patients who will benefit from immunotherapy," the group wrote. Thus, in this study, the group aimed to develop and evaluate the predictive power of a radiomics model based on F-18 FDG-PET/CT imaging features of PD-L1 expression. Moreover, radiomics can perform functional imaging of tumors at the molecular and cellular levels, reflecting the overall expression of PD-L1 in tumor lesions, they added.

Senescent cells are present in early lung tumors, but they disappear in late-stage cancers, which suggests that senescence can stop the progression of cancer. Researchers discovered that the medication slowed the growth of lung tumors. Targeting early-stage lung cancer is vital to improve survival. The SASP regulates non-cell autonomous anti-tumor responses, such as immune surveillance of premalignant cells, and we observe impaired myeloid cell recruitment to lung tumors after Tlr2 loss.