iPSC
induced pluripotent stem cells
In this study, we generated induced pluripotent stem cells (iPSC) from five sMDD patients and differentiated the iPSCs to GABAergic interneurons (GINs) and ventral forebrain organoids.
Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specification and cell lineage differentiation, advancing the study of human embryonic development and the translation of innovations in drug discovery, disease modelling and cell-based therapies.
By incorporating optogenetic proteins into induced pluripotent stem cells (iPSCs), we generated neurons that can be stimulated with specific wavelengths of light.
Assays using induced pluripotent stem cell (iPSC)-derived human neurons are emerging as powerful tools for drug discovery in neurological disease.
Generation of induced pluripotent stem cells (iPSCs) is inefficient and stochastic.
Featured in this issue is the article “Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy,” by Choi, et al, which focuses on the use of longitudinal single-cell tracking to evaluate induced pluripotent stem cell (iPSC)-derived human neurons to study Parkinson’s disease, dementia with Lewy bodies and other synucleinopathies.
The study, published in Nature Neuroscience, is the first to use induced pluripotent stem cell (iPSC) models to study PTSD.