In hopes of making it easier to deliver drugs through the skin, MIT researchers have developed a wearable patch that applies painless ultrasonic waves to the skin, creating tiny channels that drugs can pass through. This approach could lend itself to delivery of treatments for a variety of skin conditions, and could also be adapted to deliver hormones, muscle relaxants, and other drugs, the researchers say. Most drugs are delivered orally or intravenously, but the skin is a route that could offer much more targeted drug delivery for certain applications.

Improving the decision to switch from first- to second-line therapy in multiple sclerosis: A dynamic scoring system Mult Scler. Dayan CM, Lecumberri B, Muller I, Ganesananthan S, Hunter SF, Selmaj KW, Hartung HP, Havrdova EK, LaGanke CC, Ziemssen T, Van Wijmeersch B, Meuth SG, Margolin DH, Poole EM, Baker DP, Senior PA. Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies Mult Scler J Exp Transl Clin. - A swiss single center cross-sectional study Mult Scler Relat Disord.

As an international study involving University of Gothenburg researchers has shown, a decision tool for health professionals has proved capable of halving the use of antibiotics against urinary tract infections while maintaining patient safety. The background to the study is the overprescription of antibiotics for older people when urinary tract infections are suspected. The results show that the intervention was indeed effective: The outcome was a halving of the number of UTI antibiotic courses of treatment compared with the control group.

In terms of measuring telomere length at individual chromosomal ends or to characterize the length distribution of individual telomeres, the new telomere length measurement technique has the added advantage of being easy to use and producing high throughput estimates—up to 72 patient samples in a single run so far. Steps are then taken to enrich the telomere repeat-containing genomic DNA fragments using these telobaits in PacBio high fidelity sequencing.

March 9th, 2023 Proteins are made up of amino acids. It is known that reducing only protein in the diet, while maintaining the same calorie intake, produces a modest slowing of aging. In today's open access paper, researchers compare overall protein restriction with restriction of only the essential amino acid isoleucine, in both cases maintaining an overall calorie intake equivalent to that of a non-restricted diet.

In terms of measuring telomere length at individual chromosomal ends or to characterize the length distribution of individual telomeres, the new telomere length measurement technique has the added advantage of being easy to use and producing high throughput estimates—up to 72 patient samples in a single run so far. Steps are then taken to enrich the telomere repeat-containing genomic DNA fragments using these telobaits in PacBio high fidelity sequencing.

March 3rd, 2023 Proteostasis is the normal maintenance of protein levels and protein structure in a cell. Loss of proteostasis is a hallmark of aging, but has the look of a consequence of aging, not a cause to be addressed. It is also highly complex, and thus progress towards practical therapies is probably better served by a focus on causes of aging rather than the fine details of age-related changes in the cell.

In patients with newly initiated antipsychotic medications following infection-related hospitalization, discontinuation rates were lower among atypical antipsychotic users compared to haloperidol users. The primary outcome was discontinuation of the antipsychotic medication which was defined as a gap of more than 15 days following the end of a prescription dispensing. Dementia and prolonged hospitalization were also found to be inversely associated with the discontinuation of antipsychotic medications.

We have previously shown evidence for the therapeutic potential of Angiotensin- ) in reversing vasoreparative dysfunction in aging. This study tested the hypothesis that ischemic vascular repair in aging by Ang- involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells. BM cells from Old mice generated a higher number of monocytes and M1 macrophages compared to that of Young, which was reversed by Ang-. Increased expressions of these factors were decreased by Ang-.

At present, there is limited information regarding factors leading to a discontinuation of antipsychotics used for delirium, which this retrospective cohort study aimed to assess. The results of this study showed that the incidence of discontinuation within 30 days of antipsychotic initiation was 11.4% among patients using atypical antipsychotics and 52.1% among haloperidol users. The results of this study showed that of all the total participants, 8.5% had a suicide attempt.