Cardiac-specific JMJD6 overexpression in rats protected the hearts against ISO-induced cardiac hypertrophy and fibrosis, and rescued cardiac function. Histone H4R3 symmetric di-methylation by prmt5 protects against cardiac hypertrophy via regulation of Filip1L/beta-catenin. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. Yu S, Li Y, Zhao H, Wang Q, Chen P. The Histone demethylase JMJD1C regulates CAMKK2-AMPK signaling to participate in cardiac hypertrophy.

Previous studies in mouse models and in cancer patients have shown a link between microbiome abnormalities and problems in the immune system. This new study is among the first to uncover the link between Enterobacteriaceae and immune-system impairment associated with increased infection risk in critically ill patients. The research showed that the gut microbiota and systemic immunity work together as a dynamic “metasystem,” in which problems with gut microbes and immune system dysfunction are associated with significantly increased rates of hospital-acquired infections.

Twenty to 50 per cent of all critically ill patients contract potentially deadly infections during their stay in the intensive care unit or in hospital after being in the ICU – markedly increasing the risk of death. “Despite the use of antibiotics, hospital-acquired infections are a major clinical problem that persists to be a huge issue for which we don’t have good solutions,” says Dr. Braedon McDonald, MD, PhD, an intensive care physician at the Foothills Medical Centre and assistant professor at the Cumming School of Medicine.

The team’s study, involving 51 critically ill adult patients newly admitted to the ICU, found that patients who experienced an abnormal increase in the gut of a family of bacteria called Enterobacteriaceae were at the highest risk of severe infections. Previous studies in mouse models and in cancer patients have shown a link between microbiome abnormalities and problems in the immune system. This new study is among the first to uncover the link between Enterobacteriaceae and immune-system impairment associated with increased infection risk in critically ill patients.

The study, published February 13 in the journal Proceedings of the National Academy of Sciences, gives us a better understanding of how the time we exercise at impacts our metabolism at a specific tissue level. And as it turns out, according to the research, you burn more fat in the morning. The earlier you exercise, the higher the expression of genes involved in breaking down fat – which, voila, results in a higher metabolic rate.

Cognito is using goggles and headphones to emit light and sound at particular frequencies that trigger brainwaves that it believes will help stall Alzheimer's disease. That changed in 2016 when a team led by MIT neuroscientists Li-Huei Tsai and Ed Boyden figured out how to trigger gamma waves in mice, first using a complex molecular technique known as optogenetics, and later with simple light and sound stimulation. Solomon had heard of Tsai and Boyden’s research, so he agreed to run the study and found that the device increased gamma waves with few to no side effects in most participants.

Study: Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections. The results revealed that systemic immunity and the gut microbiome form an integrated metasystem, and dysbiosis in the gut results in host defense impairments, increasing the risk of hospital-acquired infections. However, continued gut microbiome dysbiosis could result in dysregulations of the adaptive immune responses during the course of ICU admission, as shown by other studies that reported apoptosis of lymphocytes and increased risk of organ dysfunction and nosocomial infections.